Bypassing multidrug resistance in cancer cells with biodegradable polymer capsules

Y Yan; CJ Ochs; GK Such; JK Heath; EC Nice; F Caruso

Journal article

Bypassing multidrug resistance in cancer cells with biodegradable polymer capsules

Y Yan, CJ Ochs, GK Such, JK Heath, EC Nice, F Caruso

Advanced Materials | Published : 2010

DOI: 10.1002/adma.201003162

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Abstract

Biodegradable polymer capsules with drug-loaded multilayers were prepared through click chemistry via layer-by-layer assembly. The capsules can efficiently release incorporated drug by intracellular enzymatic degradation in both sensitive and resistant colorectal cancer cells in vitro. Endocytosis of drug-loaded capsules leads to bypass of Pgp-mediated multidrug resistance in cancer cells. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

University of Melbourne Researchers

Georgina Such Author

Joan Heath Author

Frank Caruso Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This work was supported by the Australian Research Council under the Federation Fellowship and Discovery Project schemes (F. C.) and by the National Health and Medical Research Council (NHMRC) Program Grant 487922 (J.K.H., F. C.).